Protein Labeling Reagents
Biotium PLGF(PLGF94), CF568 conjugate, 0.1mg/mL
The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF) and Placenta Growth Factor (PLGF). Placenta growth factor (PLGF) is a secreted protein primarily produced by placental trophoblasts but also expressed in other endothelial cells and tumors. There are three isoforms, PLGF-1, PLGF-2, and PLGF-3. PLGF-2 is expressed up until week 8 in the placenta; the placental tissues continuously express PLGF-1 and PLGF-3 but only PLGF-1 is found in colon and mammary carcinomas. PLGF acts to stimulate angiogenesis, endothelial growth and migration. PLGF is a powerful promoter of tumor growth and is upregulated in some cancers, and PLGF is thought to aid in atherosclerotic lesions and neovascular growth surrounding the lesio
Biotium bcl-2(100/D5), CF488A conjugate, 0.1mg/mL
This antibody recognizes a protein of 25-26 kDa, identified as Bcl-2. This antibody shows no cross-reaction with Bcl-x or Bax proteins. Bcl-2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability. Bcl-2 appears to function in a feedback loop system with caspases. It inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Expression of Bcl-2 inhibits programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of Bcl-2 protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those foll
Biotium CD66 (CEA)(C66/195), CF568 conjugate, 0.1mg/mL
This antibody recognizes proteins of 80-200 kDa, identified as different members of CEA family. CEA is synthesized during development in the fetal gut and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. This MAb reacts with nonspecific cross-reacting antigen (NCA) and shows a cross-reaction with human polymorphonuclear leucocytes. It shows no reaction with a variety of normal tissues and is suitable for staining of formalin/paraffin tissues. CEA is not found in benign glands, stroma, or malignant prostatic cells. Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA ) from pleural mesotheliomas (rarely or weakly CEA ). Anti-CEA positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbadder, urachus, salivary gland, ovary, and endocervix.Primary antibodies are available purified, or with a selection of fluorescent CF Dy
![eMolecules Broadpharm / Sulfo-Cy5 bis-NHS ester / 1mg / 761705599 / BP-28889 / / 252255-42-8 / [null] / 975.140 / C45H51KN4O14S2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502461537.JPG-250.jpg)
eMolecules Broadpharm / Sulfo-Cy5 bis-NHS ester / 1mg / 761705599 / BP-28889 / / 252255-42-8 / [null] / 975.140 / C45H51KN4O14S2
Broadpharm / Sulfo-Cy5 bis-NHS ester / 1mg / 761705599 / BP-28889 / / 252255-42-8 / [null] / 975.140 / C45H51KN4O14S2
Agilent Technologies GLY-X VACUUM MANIFOLD SPACER
Gly-X Vacuum Manifold Spacer (2-pack) The Gly-X Vacuum Manifold Spacer ensures precise fitment of Gly-X components in the recommended Millipore MSVMHTS00-HTS vacuum manifold. Includes 2 reusable spacers.
LICOR IRDye 680RD NHS Ester (50 mg)
IRDye infrared dyes from LI-COR Biosciences are available for researchers developing applications using near-infrared (NIR) fluorescence. These unique dyes are used in a variety of NIR imaging applications including Western blotting, plate-based assays, protein arrays, tissue section imaging, and molecular activity measurements. Standard NHS ester chemistry is used to produce custom probes labeled with LI-COR IRDye infrared dyes. The NHS ester reactive group provides the functionality for labeling primary and secondary amines, such as lysine residues in proteins.
Immunochemistry Technology FAM FLICA CASPASE 1 ASSAY KIT
FAM-FLICA™ Caspase-1 Assay Kit, 25 Tests Detect caspase-1 activity with the FAM FLICA™ Caspase-1 Assay Kit. This in vitro assay employs the fluorescent inhibitor probe FAM-YVAD-FMK to label active caspase-1 enzyme in living cells or tissue samples. Analyze the green fluorescent signal using fluorescence microscopy, a fluorescent plate reader, or by flow cytometry. Caspases play important roles in apoptosis and inflammation. ICT's FLICA assay kits are used by researchers seeking to quantitate apoptosis via caspase activity in cultured cells and tissues. The FAM FLICA Caspase 1 probe allows researchers to assess caspase-1 activation.
Biocare Medical, LLC Background Sniper - 100 ml
Background Sniper is specifically formulated for superior pH stability and is sodium azide and thimerosal free. It is a universal blocking reagent used for reducing nonspecific background staining often found with immunohistochemistry, ELISA, immunoelectron microscopy and immunogold techniques. Casein has proven to be a superior blocking reagent as compared to serum proteins. It can also be used on an automated staining system.
Sigma Aldrich Fine Chemicals Biosciences 5-(IODOACETAMIDO)FLUORES 100MG
5-(Iodoacetamido)fluorescein,=90% (HPLC)
![eMolecules Broadpharm / Cy3 DBCO / 1mg / 761705892 / BP-28967 / 95.000 / 2692677-79-3 / [null] / 758.042 / C51H57N4O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502460040.PNG-250.jpg)
eMolecules Broadpharm / Cy3 DBCO / 1mg / 761705892 / BP-28967 / 95.000 / 2692677-79-3 / [null] / 758.042 / C51H57N4O2
Broadpharm / Cy3 DBCO / 1mg / 761705892 / BP-28967 / 95.000 / 2692677-79-3 / [null] / 758.042 / C51H57N4O2
![eMolecules Broadpharm / Sulfo-Cy5-TCO / 1mg / 268505169 / BP-22424 / 95.000 / 2129525-69-3 / [null] / 959.200 / C46H62N4O12S3](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502469906.JPG-250.jpg)
eMolecules Broadpharm / Sulfo-Cy5-TCO / 1mg / 268505169 / BP-22424 / 95.000 / 2129525-69-3 / [null] / 959.200 / C46H62N4O12S3
Broadpharm / Sulfo-Cy5-TCO / 1mg / 268505169 / BP-22424 / 95.000 / 2129525-69-3 / [null] / 959.200 / C46H62N4O12S3
Cayman Chemical PEO3-monamIn 250mg
A blocking reagent; prevents nonspecific adsorption of analytes in applications using covalent protein coupling; reduces the adsorption of IgG when coated on carboxylic-terminated surfaces
Cayman Chemical 13-methyl MyrIstIc AcId 25mg
A methylated fatty acid; has been found in dairy ewe rumen liquor, bovine milk, goat milk fat, the edible flesh of rainbow trout, and Flavobacterium; levels decrease in arable soil in response to heavy metal contamination